Photo: Mx. Granger, CC0 via Wikimedia Commons
Showcases numerous artifacts, mostly from the indigenous population of the area.
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Archivo Histórico Regional
The house was built by the Portuguese in the 18th century and called "Casa de Palacios". The museum shows documents from the various epochs in Colonia's history.
Museo Español
Closed for renovations as of October 2017. Here you can see everyday objects from the Spanish era, the late 18th century.
Casa del Virrey
Reconstructed somewhat on the ruins of the original building. Don't miss the whale skeleton on display just to the west of it!
Goes along the seashore with a beautiful white handrail all the way.
Museo Municipal Dr. Bautista Rebuffo
Museum in two floors presenting objects of daily life 200 years ago as well as the works of scientists and explorers that have lived and worked in the town. In the room dedicated to a biologist there are various two-, six-, and eight-legged creatures on display, as well as small and very large fossils. If you're lucky you get to meet the offspring hanging next to the fusebox in the back corner. This museum is also where you buy the U$50 ticket that allows you into all eight museums.
Iglesia Matriz
The oldest church in Uruguay. Constructed by the Portuguese in 1808, but the first church on this place was built in the 1690s.