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Referred to as Santo Domingo Oriental, this separate municipality is not very tourist-friendly. Fortunately, most of its attractions are very close to the Colonial Zone and easy to get to. Check out Los Tres Ojos, or Three Eyes, a series of open-roof caverns and underground lakes for the whole family to explore (with a local this part of Santo Domingo is the most poverty stricken and can be dangerous!). Check out the Santo Domingo Aquarium, a small but impressive showcase of the local aquatic life. If you're looking for some shopping, you can go to the Megacentro, Santo Domingo's largest shopping mall.
An important landmark because it is the first cathedral of the Americas. Construction began in 1514, and was finished in 1540.
Ozama Fortress
The oldest formal military construction still standing in the Americas. Cost of entrance is RD$200 per person and about RD$200 for a guide to take you. The guide is recommended because he will explain much of the historical background. The fortress itself is not very large, but within the perimeter you will find a large open area with a park and an exhibition of military vehicles and weapons, most of them relatively modern.
Head of state location for the Dominican Republic. No entry, but the structure is very grandiose and warm-feeling with its orange hue.
Museo Alcázar de Colón
Visit this stunning villa, built in 1510 and retaining period furnishings and other items owned by Governor Diego Colón, first-born son of Christopher Columbus. As of March 2025, it's undergoing renovations.
Museo Naval de las Atarazanas
Located across the plaza from the Alcazar de Colon on Calle Atarazana, the oldest street in the Western Hemisphere.
Museo de las Casas Reales
Another great museum featuring collections depicting life in 16th-century Santo Domingo. It is walking distance from the Alcazar de Colon and the Naval Museum. In September 2025, under renovation