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A place where you can throw some money away.
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This location offers short boat ride tours enabling you to appreciate Santa Fe from the water as well as Laguna Setabal itself. Contact info is a little lacking.
Natural history museum; great if you are wanting to see loads of taxidermy on display, but a very detailed coverage on the subject nonetheless.
In this park, you'll find a microcosm of local history in the form of the Templo y Convento San Francisco, Franciscan in nature c. 1688; the Museo Histórico Provincial de Santa Fe; and the Ethnographic Museum Colonial Juan de Garay, with excavated findings from the original Santa Fe settlement, among other things. You can also potentially see some exhibits about Pope Francis at the Colegio de la Inmaculada Concepción next door, where he went to school from 1964-1965.
House museum of a former Argentinian brigadier general.
This could be a fun little plaza just for experiencing daily Argentinian life in this city. Plus it is well visited and safer than some of the other outdoor locations.
Here is a place to see some various works of art.