Cincinnati

The city center is "Downtown" Cincinnati, sometimes referred to as the "Central Business District". With many major attractions and corporate headquarters located here, the focus of the region revolves around this district. The Cincinnati skyline is breathtaking—especially at night—when viewed from Devou Park in northern Kentucky, Mount Echo in Price Hill, or Eden Park and neighboring Mt. Adams.

Over-the-Rhine (OTR) is the city's largest historic district. Just to the north of Downtown, it is the location of Music Hall, home of the Cincinnati Symphony Orchestra and Cincinnati Opera; Findlay Market, Ohio's oldest public market in continuous operation; the Main Street Entertainment District; and much of Cincinnati's creative arts. Also of note is the Gateway Quarter a rebranded part of the neighborhood which has some of the city's hottest/hippest bars/dining spots between Central Parkway and 14th Street on Vine. Care should be taken when visiting this neighborhood as crime is more frequent here than in other areas of the city though it's going down every year. Since the 1980s, the neighborhood has been a battleground between advocates for low income housing and historic preservationists/real estate developers. As a result, the neighborhood is inconsistent in its make up, with high-end housing and shopping within viewing distance of abandoned and decayed buildings with boarded up windows. The area designated in this page as "Over-the-Rhine" also includes part of the West End neighborhood, which was ripped apart by the construction of Interstate 75 in the 1960s. The most notable landmark in this area is TQL Stadium, which opened in 2021 as the new home of FC Cincinnati, the city's Major League Soccer team.

Clifton is just north of Over-the-Rhine, from which it is separated by a steep cliff. It is home to an especially wide range of people, boasting a population diverse in ethnicity, race, sexuality, gender, age, country of origin, and economic status. A number of students at the local university inhabit the stately apartment buildings, and many of the beautiful older homes that line the gas-lit streets, though a number of families and other residents are also proud to call Clifton home. Especially notable is the stretch of Ludlow between Clifton Ave and Whitfield, as it is home to restaurants specializing in American fare and ethnic delights as well as a number of independent shops and boutiques. Northside is an economically and racially diverse neighborhood notable for a strong sense of community investment and pride. The nightlife in Northside is lively with a variety of clubs including Bronz, Mayday, Serpent, The Comet, and the Northside Tavern. The neighborhood is also home to a sizable LGBT population and hosts many of the city's gay pride events. This neighborhood is full of hipsters.

Traditionally the blue-collar side of the city, the western fringes of Cincinnati offer several attractions.

Eastern Cincinnati is known has the more upscale, white-collar part of the city, especially in neighborhoods like Mount Adams, Walnut Hills, Hyde Park, Mount Lookout, and Columbia–Tusculum. The northern reaches of this area tend towards the industrial, but have some up-and-coming neighborhoods like Oakley.