Region of Illinois in the United States
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Southern Illinois is a region in the American state of Illinois. It is primarily agricultural, like most of Illinois outside Chicagoland, but includes some attractive, rolling scenery that contrasts with the flatness of Central Illinois to its north. Distinctly southern in contrast to any other region in Illinois, Southern Illinois has a number of unique influences from the Midwest and Upland South.
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Centralia is a city in Southern Illinois.

Carbondale is a small city of about 25,000 (2020) in Southern (Illinois) about 14 miles (22 km) east of the Mississippi River at roughly the southern edge of the plains, and the northern limit of the Shawnee hills. The surrounding area boasts some pleasant countryside, particularly in the Shawnee National Forest preserve.
Makanda is a small town in Illinois.
Marion is a city in Southern Illinois. Named in honor of Francis Marion and settled in 1839, Marion isn't exactly replete with places to see but has forests and recreational areas nearby.
Metropolis is a small city in Southern Illinois probably named out of wishful thinking which hasn't really been borne out. The town's current claim to fame is as the host for a floating riverboat casino run by the Harrah's casino chain of Reno, Nevada.
Mount Vernon is a city in Illinois.
Sandoval (Pop: 1,434) is a village in Marion County, in Southern Illinois.
Staunton is a city in Southern Illinois.
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