For experienced sea kayakers only (canoes aren't safe in the open waters of Superior, and even kayaks are advised to stick close to shore) you can make your way by a series of lakeside campgrounds from Rock Harbor to Windigo, portage-free.
Guide text adapted from the Wikivoyage article "Isle Royale National Park" by its contributors, available under CC BY-SA 4.0. Read on Wikivoyage · Contributors · CC BY-SA 4.0