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If tourists or businessmen for some reason have to stay overnight in Colón and need a safe place to eat, use an ATM, stock up on supplies, etc., their best bet would be to go to the shopping plaza/cruise ship port Colón 2000. There are two restaurants there (Café Iguana and a Subway), a Super 99 grocery store, a Western Union branch, and an internet café. The main thing to emphasize is that it's 100% safe as long as you stay within the plaza area, there are both private guards and actual Panamanian police watching over it. Also in the back there are some halfway-decent souvenir shops and you can watch boats go by. How dangerous the city itself is so well-known there isn't much I could add to that, but Colón 2000 is at least one area you can breathe easy in and get some errands run if you need to.
Fuerte de San Lorenzo
This fort on the coast of the Caribbean Sea was first built in the late 16th century by the Spanish to protect present-day Panama from pirates, and was rebuilt several times afterwards. To day it's in ruins and listed as a together with the fort in Portobelo. Since 2025 it's listed twice, as it's also the northernmost point of the world heritage The Colonial Transisthmian Route of Panamá, effectively the Camino de Cruces which connected the Atlantic and Pacific back in the day.