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It hosts the Museo di Scienze Naturali with the Priolo Ornithological Collection which consists of 2250 specimens of Italian and exotic birds and butterflies.
With a façade built of black lava stone, three polygonal apses in the form of towers and 15th-century side portals in the Catalan-Gothic style. The interior is divided into three naves by black monolithic columns with statues by the Gagini school and six paintings by Giuseppe Velasquez (1750–1827).
It's the largest one in the town. It was established in the 14th century and rebuilt in 1585. It houses works by Antonello and Giacomo Gagini, and in the right nave a triptych by Messinese painters.