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The remains of a Spanish mission that was active from 1724 to 1745 can be found in the southeast section of the park. It is a few kilometers from the Bolivia-Paraguay border and Cerro San Miguel (or "Cerro de Irala").
San Ignacio de Zamucos or San Ignacio was a Jesuit mission in Santa Cruz Department, Bolivia that was founded in 1724 and abandoned in 1745. The inhabitants of the mission were the Zamucoan-speaking Ayoreo.
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